The limited information available on the structure of complexes involving transcription factors and cognate DNA response elements represents a major obstacle in the quest to understand their mechanism of action at the molecular level.We implemented a concerted structural proteomics approach, which combined hydrogen-deuterium Magazine Rack exchange
Background and objectives: Astragalus is one of the most abundant Magazine Rack genera of flowering plants in Iran.There are a few reports on phytochemical investigation of this valuable genus.Saponins, flavonoids and polysaccharides have been reported as the most important metabolites in Astragalus species.In the present research, we aimed to iden
Minimal DNA vectors exclusively comprising therapeutically relevant sequences hold great promise for the development of novel therapeutic regimen.Dumbbell-shaped vectors represent non-viral non-integrating DNA minimal vectors which have entered an advanced stage of clinical development (Hardee et al., 2017).Spliceable introns and DNA nuclear import
BackgroundAXL is a receptor tyrosine kinase that has been related to kidney and vascular disorders.Heart failure patients with reduced ejection fraction have higher AXL in serum than controls.No information about Axl expression with HF progression is available.MethodsThoracic transverse aortic constriction (TAC) was successfully performed on male W